Cyclic AMP phosphodiesterases in human lymphocytes

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Cyclic nucleotide phosphodiesterases in neoplastic and nonneoplastic human mammary tissues.

Cyclic nucleotide phosphodiesterase activity was studied in 33 malignant neoplastic, 2 benign neoplastic, and 18 nonneoplastic human mammary tissues. Enzyme activity, using both cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monosphosphate as substrates, was measured in whole homogenates over a concentration range of 1 to 100 muM. Specific activity was calculated at substrate c...

Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.

PURPOSE To characterize cyclic nucleotide phosphodiesterase isozyme activities in human trabecular meshwork cells and primary cultures of porcine trabecular meshwork cells. METHODS Radioimmunoassay of acetylated acid extracts was used to determine changes in cyclic adenosine monophosphate (cAMP) and cyclic quanosine monophosphate (cGMP) in human trabecular meshwork cells treated with phosphod...